Barcelona were held to a 1-1 home draw, a result which leaves the champions three points behind league leaders Sevilla.
A summary of Tuesday's matches in the UEFA Champions League.
Radamel Falcao's penalty ensured 10-man Atletico Madrid preserved their 100 percent home record in La Liga with a 1-0 victory over resurgent Espanyol on Sunday.
Real Madrid coach Jose Mourinho will confront the home fans who whistled him at their midweek King's Cup match by walking out alone onto the Bernabeu pitch 40 minutes before Saturday's La Liga match with Atletico Madrid.
Russian clubs ruled the Europa League roost on Thursday as Rubin Kazan upset holders Atletico Madrid while Anzhi Makhachkala and Zenit St Petersburg opened up commanding first-leg advantages in their last 32 ties.
News of all that's transpired on and off the football field
Sunderland manager Sam Allardyce reckons Atletico Madrid boss Diego Simeone would be labelled boring for his defence-oriented style if the Argentine were managing a Premier League club.
Substitute Fernando Torres scored his 100th Atletico Madrid goal as they rallied from 1-0 down to beat visiting Eibar 3-1 and go level with Barcelona at the top of La Liga on Saturday. Two headed goals from corner kicks seven minutes apart by central defenders Jose Maria Gimenez and Saul put Atletico on track after Keko had given Eibar the lead in the 46th. Coach Diego Simeone will be glad his side ended a run of four matches without a win in La Liga and the King's Cup while Torres, who netted in added time, had been waiting since a victory at Eibar in September to reach his century for the club. Atletico are unlikely to stay joint top on 51 points beyond Sunday as rampant Barcelona, who have a better goal difference and two matches in hand, visit bottom team Levante. Real Madrid, away to Granada on Sunday, are in third place, four points off the pace.
News of all that's transpired on and off the football field
A downbeat Diego Simeone did not confirm whether he wanted to continue as Atletico Madrid coach on Saturday after suffering a second agonising Champions League final defeat by Real Madrid in three years.
Juventus striker Carlos Tevez would be a perfect fit for Atletico Madrid and the La Liga club are in talks with the Argentine's agents, coach Diego Simeone has said.
Sevilla claimed their second King's Cup triumph in four years when Diego Capel's early strike and a late breakaway goal from Jesus Navas fired them to a 2-0 win over Atletico Madrid on Wednesday.
Joaquin, 37, became the oldest scorer in a Seville top-flight derby when he rose to head home at the near post in the 79th minute, shortly after the visitors had had midfielder Roque Mesa sent off for two bookings.
France forward Antoine Griezmann says he would only leave Atletico Madrid if manager Diego Simeone also quit the La Liga club.
The quarter-final draw was the last in the current format with UEFA adopting an all-new format from the 2024-25 season onwards.
Pepe opened the scoring for Real with a looping header that flew past Jan Oblak in the 52nd minute and it looked like the hosts would earn three points to move five clear of Barcelona at the top of La Liga.
Saul Niguez's second-half strike gave Atletico Madrid a 1-0 win at home to Las Palmas on Saturday, their first victory in four games in all competitions.
Karim Benzema struck twice as Real Madrid went to the top of La Liga with a 4-2 win over Villarreal on Saturday while midfielder Verza's double gave Almeria a shock 2-0 victory over Atletico Madrid.
An off-key Liverpool were frustrated for a second successive game by struggling opponents as they were held to a 0-0 Premier League draw at Newcastle United on Wednesday.
A quickfire Arda Turan double, including an acrobatic bicycle kick, fired Atletico Madrid to a 3-1 home win over Espanyol in La Liga on Sunday and lifted the Europa League semi-finalists up to seventh.
The pair, who are third and second respectively in La Liga, were hit with the bans by FIFA for breaching rules on signing non-Spanish under-18 players.
Despite striking a brace to help Atletico win Europa League title against Marseille, the French player has been heavily linked with a switch to Barcelona.
'The decision to let me leave was something that not only (Lionel) Messi didn't understand, but many Barcelona fans didn't, either.'
Atletico Madrid slipped three points behind second-placed Real Madrid after having two players sent off in a 0-0 draw at Getafe in La Liga on Sunday.
Robert Lewandowski and Raphinha both scored twice to help Barcelona thrash hosts Villarreal 5-1.
Rayo Vallecano came from behind to beat Real Madrid 3-2 on Monday with the champions failing to reclaim top spot in the standings after two consecutive games without a win.
Atletico Madrid goalkeeper Jan Oblak produced a heroic performance to repel holders Real Madrid and help secure a 0-0 draw in their Champions League quarter-final, first leg at the Calderon on Tuesday.
The Portuguese forward, who also scored a treble in the quarter-final against Bayern Munich at the Santiago Bernabeu, and five goals across that tie, is revelling in the central striker's role he has adopted this season.
Second-half headers from Diego Godin and Raul Garcia gave holders Atletico Madrid a 2-0 win over Valencia and a place in the King's Cup quarter-finals by 3-1 on aggregate.
Real Madrid have sacked coach Carlo Ancelotti after the world's richest club by income failed to win major silverware this season.
Brazilian defender Filipe Luis scored for the second game running as Atletico Madrid beat Real Sociedad 1-0 on Tuesday to rack up a fifth straight win in La Liga and provisionally consolidate third place in the standings.
At the moment I don't see me having an expiry date, I'd love to stay here for many years to come, says Real Madrid manager Carlo Ancelotti, who'll be completing a landmark on Tuesday.
Atletico Madrid are unaware of a possible transfer embargo after Spanish media reported FIFA were set to bar the club and city rivals Real Madrid from the next two windows.
The Catalan side was routed by Atletico Madrid 3-0 in the Spanish first division league.
Real Madrid fought back from two goals down as Vinicius Jr grabbed a hat-trick in a thrilling 5-2 win over visitors Borussia Dortmund in the Champions League.
Real Madrid closed to within two points of La Liga leaders Barcelona after demolishing nine-man Rayo Vallecano 10-2 while Atletico Madrid missed a chance to seize top spot outright by losing 1-0 at Malaga.
Atletico Madrid coach Diego Simeone rates Antoine Griezmann as one of the top three players in the world and says the forward owes it to his ability to work hard and the willingness to listen.
The 21-year-old is the latest youngster to join Atletico who have also brought in Argentine forward Luciano Vietto from Villarreal since the end of last season.
Lionel Messi scored in his 12th consecutive La Liga game to help leaders Barcelona earn a 1-1 draw at Valencia, allowing second-placed Atletico Madrid to close to within nine points after a 1-0 win over Real Betis on Sunday.